

Macedonia in particular has a long tradition of wine production.Grape seeds have been found dating fromNeolithic period (about 4000 BC). Moreover, grape seeds more or less resembling the varieties suitable for wine production have been found in the same region in an area where artificial irrigation was in use. These seeds date from 3000 BC. It is generally believed that the first area of vineyards in Macedonia were cultivated as early as 2800–2200 BC.The rich Macedonian wine tradition began already at the time of Philip II and Alexander the Great of the Macedonian royal family who appreciated good wine. During the Roman Empire this tradition continued, and Macedonia - part of the Eastern Roman Empire until the seventh century - was one of the most important regions for grape cultivation in the Empire. Grape growing continued after the arrival of the Slavs and was freely developed until the fourteenth century. During the period of the Ottoman Empire (1350-1918), winemaking was kept alive in Macedonia's abundant monasteries.
In the Christian religion God is presented as the keeper of a vineyard and the church as his vine. In the rite of the Holy Communion the faithful drink wine in representation of the blood of the Lord. The Orthodox Church has made
St. Tryphon guardian saint of vines and vineyard workers, thereby assimilating extremely ancient beliefs concerning vegetation and fertility. This saint had for centuries been extremely well-known and venerated in the vine-growing regions of Macedonia.